Tramadol HCl 50mg

Posted at January 7, 2011

Firm: Actavis Ireland Ltd.
Legal category: Prescription. GMS. Sport permitted.
Energetic ingredient: Tramadol HCl 50mg.
Description: Dark green and yellow tough capsule marked TK on one aspect.
Presentation: 100. Cost on request.
Indication: Moderate to extreme soreness.
Pharmacology: Tramadol is a centrally acting opioid analgesic. It is a non-selective pure agonist at μ-, δ- and κ-opioid receptors with a increased affinity for the μ-receptor. Other mechanisms which may well contribute to its analgesic impact are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release.
Dosage: Grownup: To be taken total, with adequate liquid. Acute soreness: Original dose 50-100mg each and every 4-6 hrs, depending on discomfort intensity. Maximum day-to-day dose 400mg (unless of course particular medical conditions). Continual ailments: 50mg at first, then titrate in accordance to soreness severity. Renal impairment: cc<10ml/min, not recommended; cc<30ml/min, increase dose interval to 12 hours. Elderly: Contemplate dose adjustment or boost dose interval. Youngsters: Under 12 a long time, not appropriate.
Contraindications: Hypersensitivity to the lively ingredient or the excipients. Acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropic medicinal products. Epilepsy not adequately controlled by remedy. Use in narcotic withdrawal treatment. Pregnancy, lactation.
Unique precautions: Caution: Opioid dependency, opiate sensitivity, head injury, shock, decreased consciousness of unsure origin, respiratory problems, respiratory depression, increased intercranial pressure. Convulsions may possibly happen (greater threat at doses >400mg). Threat of tolerance, psychic and physical dependence with lengthy expression use; limit remedy to short durations under strict health care supervision in individuals with tendency to drug abuse/dependence. Not appropriate as a substitute for opioid dependency. Driving/operating machines.
Drug interactions: Contraindicated: MAO inhibitors (or inside the previous 14 day). Not advisable: Mixed agonist/antagonists (e.g. buprenorphine, nalbuphine, pentazocine). Caution: CNS depressants, carbamazepine (simultaneously or previously), medication decreasing seizure threshold (e.g. serotonin re-uptake inhibitors, tricyclic antidepressants, antipsychotics), coumarin derivatives (e.g. warfarin), CYP3A4 inhibitors (e.g. ketoconazole, erythromycin), ondansetron.
Adverse drug reactions: Dizziness, headache, somnolence, nausea, vomiting, constipation, dry mouth, sweating, fatigue.
Complete prescribing data and references available from Actavis Ireland Ltd. Telephone: 1890 333231. Fax: (021) 4619049. E-mail: speak to@actavis.ie